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The present study aimed to test whether high doses of maternal NAC supplementation initiated at the time of IPTB diagnosis, would: (a) mitigate umbilical cord blood GSH depletion, (b) modify maternal and/or cord blood sulfur biomarkers, and (c) improve neonatal clinical outcomes associated with oxidative stress

Oxidative stress activates NUPR1 by both ER stress (METH [79] and H2O2 [80]) and non-ER stress pathways, NUPR1 regulates ferroptosis via iron metabolism, ROS homeostasis, and the GSH/GPX4 pathway [81, 82]

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doi: 10.1186/s13287-016-0386-0 3 BaeE